Over the years a successful cooperation was established, implemented a number of joint projects. Currently, these partnerships are actively developing. The UNICEF works in close cooperation with the Parliament of the Republic of Uzbekistan, ministries and departments, representatives of civil society and other local organizations.

The first country cooperation program began in 1995 and was aimed at ensuring continuity in the provision of basic services to children and women. By 1999, the emphasis has shifted to providing technical assistance in support of complex long-term programs. In the last decade a significant increase in resources allocated to programs of cooperation between Uzbekistan and UNICEF has been seen, and the focus of assistance was changed in order to enhance knowledge sharing and development of international best practices on issues relating to the welfare of children and women.

Uzbekistan in cooperation with UNICEF, along with 189 countries signed the Declaration on A World Fit for Children. In accordance with this document, the Government of Uzbekistan has adopted in 2007 a National Program of Action to improve the welfare of children in Uzbekistan.

Today, the activities are carried out under the Uzbekistan-UNICEF 2010-2015 Country Program dated 30 November 2009, covering such areas as maternal and child health, education, child protection, social policy and planning.